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Article

Multiple linear combination (MLC) regression tests for common variants adapted to linkage disequilibrium structure.

Genetic epidemiology - 1 Feb 2017

Yoo Yun Joo, Sun Lei, Poirier Julia G, Paterson Andrew D, Bull Shelley B

Abstract excerpt

By jointly analyzing multiple variants within a gene, instead of one at a time, gene-based multiple regression can improve power, robustness, and interpretation in genetic association analysis. We investigate multiple linear combination (MLC) test statistics for analysis of common variants under realistic trait models with linkage disequilibrium (LD) based on HapMap Asian haplotypes. MLC is a directional test...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27885705
DOI: 10.1002/gepi.22024
PMCID: PMC5245123

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