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Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease.

Genome research - 1 Nov 2012

Prabhu Snehit, Pe'er Itsik

Abstract excerpt

Long-range gene-gene interactions are biologically compelling models for disease genetics and can provide insights on relevant mechanisms and pathways. Despite considerable effort, rigorous interaction mapping in humans has remained prohibitively difficult due to computational and statistical limitations. We introduce a novel algorithmic approach to find long-range interactions in common diseases using a standard...

Topics

Algorithms
Alleles
Bipolar Disorder
Epistasis, Genetic
Genetic Loci
Genome, Human
Humans
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 22767386
DOI: 10.1101/gr.137885.112
PMCID: PMC3483552

Genes

RYR2

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