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Article

Canonical correlation analysis for gene-based pleiotropy discovery.

PLoS computational biology - 1 Oct 2014

Seoane Jose A, Campbell Colin, Day Ian N M, Casas Juan P, Gaunt Tom R

Abstract excerpt

Genome-wide association studies have identified a wealth of genetic variants involved in complex traits and multifactorial diseases. There is now considerable interest in testing variants for association with multiple phenotypes (pleiotropy) and for testing multiple variants for association with a single phenotype (gene-based association tests). Such approaches can increase statistical power by combining evidence...

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Identifiers

PMID: 25329069
DOI: 10.1371/journal.pcbi.1003876
PMCID: PMC4199483

Genes

NRG1
ACSM3
ERI2
NSF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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