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Article

Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits.

Genetics - 1 Aug 2017

Zhan Xiang, Zhao Ni, Plantinga Anna, Thornton Timothy A, Conneely Karen N, Epstein Michael P, Wu Michael C

Abstract excerpt

Many genetic association studies collect a wide range of complex traits. As these traits may be correlated and share a common genetic mechanism, joint analysis can be statistically more powerful and biologically more meaningful. However, most existing tests for multiple traits cannot be used for high-dimensional and possibly structured traits, such as network-structured transcriptomic pathway expressions. To...

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Identifiers

PMID: 28642271
DOI: 10.1534/genetics.116.199646
PMCID: PMC5560787

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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