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Article

Complex-disease networks of trait-associated single-nucleotide polymorphisms (SNPs) unveiled by information theory.

Journal of the American Medical Informatics Association : JAMIA - 1 Jan 2000

Li Haiquan, Lee Younghee, Chen James L, Rebman Ellen, Li Jianrong, Lussier Yves A

Abstract excerpt

OBJECTIVE: Thousands of complex-disease single-nucleotide polymorphisms (SNPs) have been discovered in genome-wide association studies (GWAS). However, these intragenic SNPs have not been collectively mined to unveil the genetic architecture between complex clinical traits. The authors hypothesize that biological annotations of host genes of trait-associated SNPs may reveal the biomolecular modularity across...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22278381
DOI: 10.1136/amiajnl-2011-000482
PMCID: PMC3277620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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