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Article

Calcium intake and ion transporter genetic polymorphisms interact in human colorectal neoplasia risk in a 2-phase study.

The Journal of nutrition - 1 Nov 2014

Zhu Xiangzhu, Liang Ji, Shrubsole Martha J, Ness Reid M, Cai Qiuyin, Long Jirong, Chen Zhi, Li Guoliang, Wiese Dawn, Zhang Bing, Smalley Walter E, Edwards Todd L, Giovannucci Edward, Zheng Wei, Dai Qi

Abstract excerpt

BACKGROUND: The kidney-specific sodium-potassium-chloride cotransporter (NKCC2) protein encoded by solute carrier family 12 member 1 (SLC12A1) is the direct downstream effector of the inward-rectifier potassium channel (ROMK) encoded by potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1), both of which are critical for calcium reabsorption in the kidney. OBJECTIVE: We hypothesized that...

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Source

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Identifiers

PMID: 25165391
DOI: 10.3945/jn.114.196709
PMCID: PMC4195417

Genes

KCNJ1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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