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Article

Genetic variation in SLC7A2 interacts with calcium and magnesium intakes in modulating the risk of colorectal polyps.

The Journal of nutritional biochemistry - 1 Sept 2017

Sun Pin, Zhu Xiangzhu, Shrubsole Martha J, Ness Reid M, Hibler Elizabeth A, Cai Qiuyin, Long Jirong, Chen Zhi, Li Guoliang, Hou Lifang, Smalley Walter E, Edwards Todd L, Giovannucci Edward, Zheng Wei, Dai Qi

Abstract excerpt

Solute carrier family 7, member 2 (SLC7A2) gene encodes a protein called cationic amino acid transporter 2, which mediates the transport of arginine, lysine and ornithine. l-Arginine is necessary for cancer development and progression, including an important role in colorectal cancer pathogenesis. Furthermore, previous studies found that both calcium and magnesium inhibit the transport of arginine. Thus, calcium,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28501704
DOI: 10.1016/j.jnutbio.2017.04.016
PMCID: PMC5583031

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