Article
Interactions between calcium intake and polymorphisms in genes essential for calcium reabsorption and risk of colorectal neoplasia in a two-phase study.
Molecular carcinogenesis - 1 Oct 2017
Zhao Jing, Zhu Xiangzhu, Shrubsole Martha J, Ness Reid M, Hibler Elizabeth A, Cai Qiuyin, Long Jirong, Chen Zhi, Jiang Ming, Kabagambe Edmond K, Zhang Bing, Hou Lifang, Smalley Walter E, Edwards Todd L, Giovannucci Edward L, Zheng Wei, Dai Qi
Abstract excerpt
The SLC8A1 (solute carrier family 8, member 1) gene, encoding Na+ /Ca2+ exchanger, is essential in regulating calcium reabsorption and homeostasis. Calcium homeostasis plays a key role in cell proliferation and apoptosis. We hypothesized that polymorphisms in five calcium-regulating genes (SLC8A1, ATP2B1, CALB1, CALB2, and CABP1) interact with calcium intake in relation to the risk of colorectal neoplasia. A...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.