Article
No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Dec 2014
Du Mengmeng, Zhang Xuehong, Hoffmeister Michael, Schoen Robert E, Baron John A, Berndt Sonja I, Brenner Hermann, Carlson Christopher S, Casey Graham, Chan Andrew T, Curtis Keith R, Duggan David, Gauderman W James, Giovannucci Edward L, Gong Jian, Harrison Tabitha A, Hayes Richard B, Henderson Brian E, Hopper John L, Hsu Li, Hudson Thomas J, Hutter Carolyn M, Jenkins Mark A, Jiao Shuo, Kocarnik Jonathan M, Kolonel Laurence N, Le Marchand Loic, Lin Yi, Newcomb Polly A, Rudolph Anja, Seminara Daniela, Thornquist Mark D, Ulrich Cornelia M, White Emily, Wu Kana, Zanke Brent W, Campbell Peter T, Slattery Martha L, Peters Ulrike, Chang-Claude Jenny, Potter John D
Abstract excerpt
BACKGROUND: Calcium intake may reduce risk of colorectal cancer, but the mechanisms remain unclear. Studies of interaction between calcium intake and SNPs in calcium-related pathways have yielded inconsistent results. METHODS: To identify gene-calcium interactions, we tested interactions between approximately 2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental...
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