Article
Calcium/magnesium intake ratio, but not magnesium intake, interacts with genetic polymorphism in relation to colorectal neoplasia in a two-phase study.
Molecular carcinogenesis - 1 Oct 2016
Zhu Xiangzhu, Shrubsole Martha J, Ness Reid M, Hibler Elizabeth A, Cai Qiuyin, Long Jirong, Chen Zhi, Li Guoliang, Jiang Ming, Hou Lifang, Kabagambe Edmond K, Zhang Bing, Smalley Walter E, Edwards Todd L, Giovannucci Edward L, Zheng Wei, Dai Qi
Abstract excerpt
Some studies suggest that the calcium to magnesium ratio intakes modify the associations of calcium or magnesium with risk of colorectal adenoma, adenoma recurrence, and cancer. Parathyroid hormone (PTH) plays a key role in the regulation of homeostasis for both calcium and magnesium. We hypothesized that polymorphisms in PTH and 13 other genes may modify the association between the calcium/magnesium intake ratio...
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