Article
Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.
PloS one - 1 Jan 2014
Zhou Yinghui, Rideout William M, Bressel Angela, Yalavarthi Sireesha, Zi Tong, Potz Darren, Farlow Samuel, Brodeur Joelle, Monti Anthony, Reddipalli Shailaja, Xiao Qiurong, Bottega Steve, Feng Bin, Chiu M Isabel, Bosenberg Marcus, Heyer Joerg
Abstract excerpt
Colon cancer is the second most common cause of cancer mortality in the Western world with metastasis commonly present at the time of diagnosis. Screening for propagation and metastatic behavior in a novel chimeric-mouse colon cancer model, driven by mutant p53 and β-Catenin, led to the identification of a unique, invasive adenocarcinoma. Comparison of the genome of this tumor, CB42, with genomes from...
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