Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth.

Abstract excerpt

Landmark cancer genome resequencing efforts are leading to the identification of mutated genes in many types of cancer. The extreme diversity of mutations being detected presents significant challenges to subdivide causal from coincidental mutations to elucidate how disrupted regulatory networks drive cancer processes. Given that a common early perturbation in solid tumor initiation is bypass of matrix-dependent...

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