The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

doi:10.1016/j.molmet.2020.101015

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Article

The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.

Molecular metabolism - 1 Oct 2020

Carrat Gaelle R, Haythorne Elizabeth, Tomas Alejandra, Haataja Leena, Müller Andreas, Arvan Peter, Piunti Alexandra, Cheng Kaiying, Huang Mutian, Pullen Timothy J, Georgiadou Eleni, Stylianides Theodoros, Amirruddin Nur Shabrina, Salem Victoria, Distaso Walter, Cakebread Andrew, Heesom Kate J, Lewis Philip A, Hodson David J, Briant Linford J, Fung Annie C H, Sessions Richard B, Alpy Fabien, Kong Alice P S, Benke Peter I, Torta Federico, Teo Adrian Kee Keong, Leclerc Isabelle, Solimena Michele, Wigley Dale B, Rutter Guy A

Abstract excerpt

OBJECTIVE: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve as a mediator of intracellular lipid transfer, the identity of the transported lipids and thus the pathways through which STARD10 regulates β-cell function are not...

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Identifiers

PMID: 32416313
DOI: 10.1016/j.molmet.2020.101015
PMCID: PMC7322359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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