Article

Pancreatic beta-cell specific deletion of VPS41 causes diabetes due to defects in insulin secretion

2020-04-26

Abstract excerpt

Insulin secretory granules (SGs) mediate the regulated secretion of insulin, which is essential for glucose homeostasis. The basic machinery responsible for this regulated exocytosis consists of specific proteins present both at the plasma membrane and on insulin SGs. The protein composition of insulin SGs thus dictates their release properties, yet the mechanisms controlling insulin SG formation, which determines...

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Literature Corpus work: a149f85a-ebd8-5b69-8235-ecadba54f5f7
DOI: 10.1101/2020.04.25.043729

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