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Article

RNA-sequencing of WFS1-deficient pancreatic islets.

Physiological reports - 1 Apr 2016

Ivask Marilin, Hugill Alison, Kõks Sulev

Abstract excerpt

Wolfram syndrome, an autosomal recessive disorder characterized by juvenile-onset diabetes mellitus and optic atrophy, is caused by mutations in theWFS1gene.WFS1encodes an endoplasmic reticulum resident transmembrane protein. TheWfs1-null mice exhibit progressive insulin deficiency and diabetes. The aim of this study was to describe the insulin secretion and transcriptome of pancreatic islets inWFS1-deficient...

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Source

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Identifiers

PMID: 27053292
DOI: 10.14814/phy2.12750
PMCID: PMC4831324

Genes

WFS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RNA-sequencing of WFS1-deficient pancreatic islets.PMID 27053292Read ↗

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ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome modelsSemantic proximity Read ↗

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.Semantic proximity Read ↗

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Defects of WFS1-mediated peptide hormones secretion contribute to the manifestations of Wolfram syndrome.Semantic proximity Read ↗

Endoplasmic reticulum stress induces Wfs1 gene expression in pancreatic β-cells via transcriptional activationSemantic proximity Read ↗

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.Semantic proximity Read ↗

WFS1-related isolated diabetes induced by a WFS1 missense mutation: focus on the isolated diabetes phenotype.Semantic proximity Read ↗

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Liraglutide treatment reverses unconventional cellular defects in induced pluripotent stem cell-derived β cells harboring a partially functional WFS1 variantSemantic proximity Read ↗

WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.Semantic proximity Read ↗

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