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Article

Malaria's deadly grip: cytoadhesion of Plasmodium falciparum -infected erythrocytes

19 Aug 2013

Abstract excerpt

Cytoadhesion of Plasmodium falciparum-infected erythrocytes to host microvasculature is a key virulence determinant. Parasite binding is mediated by a large family of clonally variant adhesion proteins, termed P. falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by var genes and expressed at the infected erythrocyte surface. Although PfEMP1 proteins have extensively diverged under opposing selection...

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PMID: 23957661
DOI: 10.1111/cmi.12183

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