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Article

Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype.

Pharmacogenomics - 1 Jul 2014

Matic Maja, Simons Sinno H P, van Lingen Richard A, van Rosmalen Joost, Elens Laure, de Wildt Saskia N, Tibboel Dick, van Schaik Ron H N

Abstract excerpt

AIM: Determine whether SNPs of OPRM1 118A>G (asn(40)asp), COMT 472G>A (val(158)met) and ARRB2 8622C>T are associated with morphine rescue in newborns on mechanical ventilation. MATERIALS & METHODS: This is a pharmacogenetic analysis of a randomized controlled trial in (pre)term newborns (n = 64) at a level III Neonatal Intensive Care Unit (NICU) who received placebo infusion and for whom need and dose for rescue...

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Share to Catechol O-Methyltransferase
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Infant, Newborn

Share to Morphine

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 25155931
DOI: 10.2217/pgs.14.100

Genes

COMT
OPRM1
ARRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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