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Article

The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.

Biological research for nursing - 1 Jul 2013

Henker Richard A, Lewis Allison, Dai Feng, Lariviere William R, Meng Li, Gruen Gary S, Sereika Susan M, Pape Hans, Tarkin Ivan S, Gowda Indira, Conley Yvette P

Abstract excerpt

Previous studies have associated mu-opioid receptor (OPRM1) genotype with pain and analgesia responses in postoperative and patient populations. This study investigates the role of catechol-O-methyltransferase (COMT) and OPRM1 genotypes in acute postoperative pain scores, opioid use, and opioid-induced sedation after surgical procedures for orthopedic trauma in an otherwise healthy patient population. Verbal...

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Topics

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Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Hypnotics and Sedatives

Share to Pain Measurement

Share to Pain, Postoperative

Share to Polymorphism, Single Nucleotide

Share to Receptors, Opioid, mu

Source

Open in PubMed Open full text

Identifiers

PMID: 22718527
DOI: 10.1177/1099800411436171
PMCID: PMC3815675

Genes

COMT
OPRM1
NPS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.PMID 22718527Read ↗

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