Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain.

European journal of clinical pharmacology - 1 Sept 2013

De Gregori Manuela, Garbin Giulia, De Gregori Simona, Minella Cristina E, Bugada Dario, Lisa Antonella, Govoni Stefano, Regazzi Mario, Allegri Massimo, Ranzani Guglielmina N

Abstract excerpt

PURPOSE: To investigate interindividual variability in response to pain treatment, we characterized postoperative patients for morphine metabolism and for COMT, OPRM1 and UGT2B7 polymorphisms. METHODS: A total of 109 patients treated with morphine were genotyped by DNA sequencing for 12 DNA polymorphisms of the COMT, OPRM1 and UGT2B7 genes. The plasma concentration of morphine and of M3G/M6G metabolites were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analgesics, Opioid
Share to Catechol O-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Morphine

Share to Pain, Postoperative

Share to Receptors, Opioid, mu

Share to Treatment Outcome

Share to Young Adult

Source

Identifiers

PMID: 23686330
DOI: 10.1007/s00228-013-1523-7

Genes

COMT
OPRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variability at COMT but not at OPRM1 and UGT2B7 loci modulates morphine analgesic response in acute postoperative pain.PMID 23686330Read ↗

The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.Semantic proximity Read ↗

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.Semantic proximity Read ↗

Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study.Semantic proximity Read ↗

OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma.Semantic proximity Read ↗

Human Genetic Variability Contributes to Postoperative Morphine Consumption.Semantic proximity Read ↗

Pain polymorphisms and opioids: An evidence based reviewSemantic proximity Read ↗

Exploring joint effects of genes and the clinical efficacy of morphine for cancer pain: OPRM1 and COMT gene.Semantic proximity Read ↗

Genetics and genomics in postoperative pain and analgesia.Semantic proximity Read ↗

Genotyping test with clinical factors: better management of acute postoperative pain?Semantic proximity Read ↗

COMT gene haplotypes are closely associated with postoperative fentanyl dose in patients.Semantic proximity Read ↗

Review of Opioid Pharmacogenetics and Considerations for Pain ManagementSemantic proximity Read ↗

Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.