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Article

Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome.

JAMA - 1 May 2013

Wachman Elisha M, Hayes Marie J, Brown Mark S, Paul Jonathan, Harvey-Wilkes Karen, Terrin Norma, Huggins Gordon S, Aranda Jacob V, Davis Jonathan M

Abstract excerpt

IMPORTANCE: Neonatal abstinence syndrome (NAS) caused by in utero opioid exposure is a growing problem; genetic factors influencing the incidence and severity have not been previously examined. Single-nucleotide polymorphisms (SNPs) in the μ-opioid receptor (OPRM1), multidrug resistance (ABCB1), and catechol-o-methyltransferase (COMT) genes are associated with risk for opioid addiction in adults. OBJECTIVE: To...

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Identifiers

PMID: 23632726
DOI: 10.1001/jama.2013.3411
PMCID: PMC4432911

Genes

COMT
OPRM1
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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