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Article

Can pharmacogenetics inform morphine dosing in the neonatal intensive care unit? A retrospective evaluation.

Clinica chimica acta; international journal of clinical chemistry - 15 Feb 2026

Mankouski Anastasiya, Brunelli Luca, McMillin Gwendolyn

Abstract excerpt

Acutely ill infants in the neonatal intensive care unit (NICU) present with complex medical conditions necessitating individualized therapeutic strategies. These infants exhibit significant variability in gestational age, birth weight, organ maturity and drug metabolism, increasing the risk of adverse drug reactions. Morphine is commonly prescribed in the NICU and is associated with a wide range of dosing as well...

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Share to Catechol O-Methyltransferase
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Infant, Newborn

Share to Intensive Care Units, Neonatal

Share to Morphine

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Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 41478610
DOI: 10.1016/j.cca.2025.120814

Genes

COMT
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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