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Article

Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity.

The American journal on addictions - 1 Jan 2017

Wachman Elisha M, Hayes Marie J, Sherva Richard, Brown Mark S, Shrestha Hira, Logan Beth A, Heller Nicole A, Nielsen David A, Farrer Lindsay A

Abstract excerpt

BACKGROUND AND OBJECTIVES: There is significant variability in severity of neonatal abstinence syndrome (NAS) due to in utero opioid exposure. Our previous study identified single nucleotide polymorphisms (SNPs) in the prepronociceptin (PNOC) and catechol-O-methyltransferase (COMT) genes that were associated with differences in NAS outcomes. This study looks at the same SNPs in PNOC and COMT in an independent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Infant, Newborn

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Share to Polymorphism, Single Nucleotide

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Share to Receptors, Opioid

Source

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Identifiers

PMID: 27983768
DOI: 10.1111/ajad.12483
PMCID: PMC5206487

Genes

COMT
PNOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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