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Article

Genetic Predisposition to Poor Opioid Response in Preterm Infants: Impact of KCNJ6 and COMT Polymorphisms on Pain Relief After Endotracheal Intubation.

Therapeutic drug monitoring - 1 Aug 2016

Elens Laure, Norman Elisabeth, Matic Maja, Rane Anders, Fellman Vineta, van Schaik Ron H N

Abstract excerpt

BACKGROUND: Single-nucleotide polymorphisms in genes involved in pain control might predispose to exaggerated sensitivity or difference in opioid analgesic effect. The relevance of the KCNJ6 -1250G>A (rs6517442, c.-1787G>A) and the catecholamine-O-methyltransferase (COMT) c.472G>A (rs4680, ValMet) single-nucleotide polymorphisms were studied in preterm infants needing intubation and randomized to a premedication...

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Share to Analgesics, Opioid
Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels
Share to Infant, Premature
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Source

Identifiers

PMID: 27027462
DOI: 10.1097/FTD.0000000000000301

Genes

COMT
KCNJ6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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