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Article

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.

Pharmacogenomics - 1 Aug 2017

Matic Maja, Jongen Joost Lm, Elens Laure, de Wildt Saskia N, Tibboel Dick, Sillevis Smitt Peter Ae, van Schaik Ron Hn

Abstract excerpt

AIM: To assess association between genetic variants and opioid requirement in cancer patients. MATERIALS & METHODS: A prospective observational trial of 243 advanced cancer patients with inadequate analgesia treated by the palliative care team was analyzed for ABCB1, ARRB2, COMT, GCH1, IL1RN, KCNJ6, OPRM1, RHBDF2, SCN9A and Stat6 polymorphisms. RESULTS: For patients carrying OPRM1 118AG/GG and COMT 472GG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28745577
DOI: 10.2217/pgs-2017-0060

Genes

COMT
OPRM1
ABCB1
ARRB2
GCH1
KCNJ6
RHBDF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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