Article
A further investigation of combined mismatch repair and BRAFV600E mutation specific immunohistochemistry as a predictor of overall survival in colorectal carcinoma.
PloS one - 1 Jan 2014
Luey Nathan, Toon Christopher W, Sioson Loretta, Clarkson Adele, Watson Nicole, Cussigh Carmen, Kedziora Andrew, Pincott Stuart, Pillinger Stephen, Evans Justin, Percy John, Engel Alexander, Schnitzler Margaret, Gill Anthony J
Abstract excerpt
Mutation specific immunohistochemistry (IHC) is a promising new technique to detect the presence of the BRAFV600E mutation in colorectal carcinoma (CRC). When performed in conjunction with mismatch repair (MMR) IHC, BRAFV600E IHC can help to further triage genetic testing for Lynch Syndrome. In a cohort of 1426 patients undergoing surgery from 2004 to 2009 we recently demonstrated that the combination of MMR and...
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