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Article

Impact of BRAF Gene Mutation in Nonmetastatic Colorectal Cancer on Disease Progression and Survival Outcomes.

Journal of gastroenterology and hepatology - 1 Feb 2026

Lum Caroline, Boka Harrison, Asghari-Jafarabadi Mohammad, Mendis Shehara, Cohen Lauren, Abud Helen E, Engel Rebekah M, McMurrick Paul J

Abstract excerpt

BACKGROUND AND AIM: Colorectal cancer (CRC) is a major global health concern, with molecular and histopathological subtypes influencing disease progression. Mutations in the v-Raf murine sarcoma viral oncogene homolog B (BRAF) gene, particularly the V600E variant, define a subset associated with aggressive features. The impact of BRAF mutations on early-stage CRC prognosis and their interaction with mismatch...

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PMID: 41574648
DOI: 10.1111/jgh.70215

Genes

BRAF

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