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Article

BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2014

Toon Christopher W, Chou Angela, DeSilva Keshani, Chan Joseph, Patterson Jillian, Clarkson Adele, Sioson Loretta, Jankova Lucy, Gill Anthony J

Abstract excerpt

Immunohistochemistry has recently been validated for the detection of the BRAFV600E mutation across a range of tumor types. In colorectal carcinoma, the presence of the BRAFV600E mutation can be used to virtually exclude Lynch syndrome in mismatch repair-deficient tumors. In mismatch repair-proficient tumors, BRAFV600E mutation assessed by molecular methods has been proposed as a poor prognostic factor. We...

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Source

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Identifiers

PMID: 24157612
DOI: 10.1038/modpathol.2013.200
PMCID: PMC4021849

Genes

BRAF
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer.PMID 24157612Read ↗

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BRAFV600E immunohistochemistry can reliably substitute BRAF molecular testing in the Lynch syndrome screening algorithm in colorectal cancer.Semantic proximity Read ↗

BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome.Semantic proximity Read ↗

Systematic immunohistochemical screening for Lynch syndrome in colorectal cancer: a single centre experience of 486 patients.Semantic proximity Read ↗

Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinomaSemantic proximity Read ↗

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