BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer.

doi:10.1038/modpathol.2013.200

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Article

BRAFV600E immunohistochemistry in conjunction with mismatch repair status predicts survival in patients with colorectal cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2014

Toon Christopher W, Chou Angela, DeSilva Keshani, Chan Joseph, Patterson Jillian, Clarkson Adele, Sioson Loretta, Jankova Lucy, Gill Anthony J

Abstract excerpt

Immunohistochemistry has recently been validated for the detection of the BRAFV600E mutation across a range of tumor types. In colorectal carcinoma, the presence of the BRAFV600E mutation can be used to virtually exclude Lynch syndrome in mismatch repair-deficient tumors. In mismatch repair-proficient tumors, BRAFV600E mutation assessed by molecular methods has been proposed as a poor prognostic factor. We...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Carcinoma
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mismatch Repair
Female
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunohistochemistry

Male

Microsatellite Instability

Middle Aged

Mutation

Proto-Oncogene Proteins B-raf

Survival Rate

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24157612
DOI: 10.1038/modpathol.2013.200
PMCID: PMC4021849

Genes

BRAF
MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24157612-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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