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Article

BRAFV600E immunohistochemistry can reliably substitute BRAF molecular testing in the Lynch syndrome screening algorithm in colorectal cancer.

Histopathology - 1 Apr 2024

Grillo Federica, Paudice Michele, Pigozzi Simona, Dono Maria, Lastraioli Sonia, Lugaresi Marialuisa, Bozzano Silvia, Tognoni Camilla, Ali Murad, Sciallero Stefania, Puccini Alberto, Fassan Matteo, Mastracci Luca

Abstract excerpt

AIMS: The Lynch syndrome (LS) screening algorithm requires BRAF testing as a fundamental step to distinguish sporadic from LS-associated colorectal carcinomas (CRC). BRAF testing by immunohistochemistry (IHC) has shown variable results in the literature. Our aim was to analyse concordance between BRAFV600E IHC and BRAF molecular analysis in a large, mono-institutional CRC whole-slide, case series with laboratory...

Topics

Humans
Colorectal Neoplasms, Hereditary Nonpolyposis
Immunohistochemistry
Proto-Oncogene Proteins B-raf
Early Detection of Cancer
Colorectal Neoplasms
Molecular Diagnostic Techniques
Algorithms
DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Brain Neoplasms

Neoplastic Syndromes, Hereditary

Source

Identifiers

PMID: 38173291
DOI: 10.1111/his.15133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-38173291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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