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Article

CMS-dependent prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 May 2018

Smeby J, Sveen A, Merok M A, Danielsen S A, Eilertsen I A, Guren M G, Dienstmann R, Nesbakken A, Lothe R A

Abstract excerpt

Background: The prognostic impact of KRAS and BRAFV600E mutations in primary colorectal cancer (CRC) varies with microsatellite instability (MSI) status. The gene expression-based consensus molecular subtypes (CMSs) of CRC define molecularly and clinically distinct subgroups, and represent a novel stratification framework in biomarker analysis. We investigated the prognostic value of these mutations within the...

Topics

Adult
Aged
Aged, 80 and over
Biomarkers, Tumor
Cohort Studies
Colorectal Neoplasms
DNA Mutational Analysis
Datasets as Topic
Disease-Free Survival
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Profiling

Humans

Male

Microsatellite Instability

Middle Aged

Mutation

Norway

Predictive Value of Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 29518181
DOI: 10.1093/annonc/mdy085
PMCID: PMC5961317

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29518181-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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