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Development and Characterization of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PEPT1

22 Aug 2014

Abstract excerpt

The proton-coupled oligopeptide transporter PEPT1 (SLC15A1) is abundantly expressed in the small intestine, but not colon, of mammals and found to mediate the uptake of di/tripeptides and peptide-like drugs from the intestinal lumen. However, species differences have been observed in both the expression (and localization) of PEPT1 and its substrate affinity. With this in mind, the objectives of this study were to...

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PMID: 25148225
DOI: 10.1021/mp500497p

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