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Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

2018-07-23

Abstract excerpt

Enteroendocrine cells (EECs) produce hormones that regulate food absorption, insulin secretion and appetite. Both EECs and their peptide products are foci of drug discovery programmes for diabetes and obesity. We compared the human and mouse EEC transcriptome and peptidome to validate mouse as a model of the human enteroendocrine axis. We present the first RNA sequencing analysis of human EECs, and demonstrate str...

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Identifiers and source

Literature Corpus work
7230f8e8-1045-50ea-9208-09bfb58e4eb8
DOI
10.1101/374579
Open publication

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Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profilingDOI 10.1101/374579
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