Article
Crystal Structures of the Extracellular Domain from PepT1 and PepT2 Provide Novel Insights into Mammalian Peptide Transport.
Structure (London, England : 1993) - 6 Oct 2015
Beale John H, Parker Joanne L, Samsudin Firdaus, Barrett Anne L, Senan Anish, Bird Louise E, Scott David, Owens Raymond J, Sansom Mark S P, Tucker Stephen J, Meredith David, Fowler Philip W, Newstead Simon
Abstract excerpt
Mammals obtain nitrogen via the uptake of di- and tri-peptides in the gastrointestinal tract through the action of PepT1 and PepT2, which are members of the POT family of proton-coupled oligopeptide transporters. PepT1 and PepT2 also play an important role in drug transport in the human body. Recent crystal structures of bacterial homologs revealed a conserved peptide-binding site and mechanism of transport....
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