Article
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.
Inflammatory bowel diseases - 1 Apr 2014
Wuensch Tilo, Ullrich Sina, Schulz Stephan, Chamaillard Mathias, Schaltenberg Nicola, Rath Eva, Goebel Ulf, Sartor R Balfour, Prager Matthias, Büning Carsten, Bugert Peter, Witt Heiko, Haller Dirk, Daniel Hannelore
Abstract excerpt
BACKGROUND: PEPT1 was proposed to be expressed only in inflamed colonic tissues in which it could contribute to inflammatory bowel disease (IBD) development by transporting bacterial peptides, such as muramyl dipeptide (MDP), that activate intracellular pattern recognition receptors, such as the nucleotide-binding and oligomerization domain 2. To better define the pathological relevance of this transporter, we...
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