Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter.

The Journal of pharmacology and experimental therapeutics - 1 Nov 2001

Chu X Y, Sánchez-Castaño G P, Higaki K, Oh D M, Hsu C P, Amidon G L

Abstract excerpt

The proton-coupled oligopeptide transporter (PEPT1) has been shown to mediate mucosal cell transport of di- and tripeptide, and some peptidomimetic drugs. In this study, we determined the correlation between PEPT1 protein expression and the permeability of cephalexin, a substrate of PEPT1, in human PEPT1 (hPEPT1)-overexpressed Caco-2 cells (Caco-2/hPEPT1 cells) and rat jejunum. Caco-2/hPEPT1 cells with various...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caco-2 Cells
Share to Cell Membrane Permeability

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cephalosporins

Share to Chromatography, High Pressure Liquid

Share to Intestinal Absorption

Share to Perfusion

Share to Rats, Sprague-Dawley

Share to Symporters

Source

Identifiers

PMID: 11602669

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Correlation between epithelial cell permeability of cephalexin and expression of intestinal oligopeptide transporter.PMID 11602669Read ↗

Development and Characterization of a Novel Mouse Line Humanized for the Intestinal Peptide Transporter PEPT1Semantic proximity Read ↗

Expression, regulation and function of intestinal drug transporters: an updateSemantic proximity Read ↗

Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.Semantic proximity Read ↗

Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2Semantic proximity Read ↗

Drug-Permeability and Transporter Assays in Caco-2 and Mdck Cell LinesSemantic proximity Read ↗

Compartmentalized Accumulation of cAMP near Complexes of Multidrug Resistance Protein 4 (MRP4) and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Contributes to Drug-induced DiarrheaSemantic proximity Read ↗

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxinsSemantic proximity Read ↗

A Human Colonic Cell Line Sharing Similarities With Enterocytes as a Model to Examine Oral Absorption: Advantages and Limitations of the Caco-2 ModelSemantic proximity Read ↗

Evidence that the rabbit proton-peptide co-transporter PepT1 is a multimer when expressed in Xenopus laevis oocytes.Semantic proximity Read ↗

Quantification of protein transcytosis in the human colon carcinoma cell line CaCo‐2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.