Article
Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2017
Stelzl Tamara, Geillinger-Kästle Kerstin E, Stolz Jürgen, Daniel Hannelore
Abstract excerpt
Despite the fact that many membrane proteins carry extracellular glycans, little is known about whether the glycan chains also affect protein function. We recently demonstrated that the proton-coupled oligopeptide transporter 1 (PEPT1) in the intestine is glycosylated at six asparagine residues (N50, N406, N439, N510, N515, and N532). Mutagenesis-induced disruption of the individual N-glycosylation site N50,...
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