Article
Copy number variations could predict the outcome of bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Genes, chromosomes & cancer - 1 Jan 2015
Kim Myungshin, Lee Shin Hyo, Kim Jiyeon, Lee Sung-Eun, Kim Yoo-Jin, Min Chang-Ki
Abstract excerpt
We performed single nucleotide polymorphism (SNP) array analysis of 35 newly diagnosed symptomatic multiple myeloma (MM) patients who received bortezomib-melphalan-prednisone (VMP) to identify collaborating genetic events that could predict the outcome of treatment. A total of 340 copy number variations (CNVs) were identified, with the most frequently identified CNVs being gains on 1q, 19p, 9q, 3q, 9p, 15q, 19q,...
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