Article
SNP-based mapping arrays reveal high genomic complexity in monoclonal gammopathies, from MGUS to myeloma status.
Leukemia - 1 Dec 2012
López-Corral L, Sarasquete M E, Beà S, García-Sanz R, Mateos M V, Corchete L A, Sayagués J M, García E M, Bladé J, Oriol A, Hernández-García M T, Giraldo P, Hernández J, González M, Hernández-Rivas J M, San Miguel J F, Gutiérrez N C
Abstract excerpt
Genetic events mediating transformation from premalignant monoclonal gammopathies (MG) to multiple myeloma (MM) are unknown. To obtain a comprehensive genomic profile of MG from the early to late stages, we performed high-resolution analysis of purified plasma cells from 20 MGUS, 20 smoldering MM (SMM) and 34 MM by high-density 6.0 SNP array. A progressive increase in the incidence of copy number abnormalities...
Topics
- Chromosome Aberrations
- Chromosome Mapping
- Chromosomes, Human
- Cytogenetic Analysis
- Gene Dosage
- Genomics
- Humans
- Loss of Heterozygosity
- Multiple Myeloma
- Nucleic Acid Hybridization