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A SNP microarray and FISH-based procedure to detect allelic imbalances in multiple myeloma: an integrated genomics approach reveals a wide gene dosage effect.

Genes, chromosomes & cancer - 1 Jul 2009

Agnelli Luca, Mosca Laura, Fabris Sonia, Lionetti Marta, Andronache Adrian, Kwee Ivo, Todoerti Katia, Verdelli Donata, Battaglia Cristina, Bertoni Francesco, Deliliers Giorgio Lambertenghi, Neri Antonino

Abstract excerpt

Multiple myeloma (MM) is characterized by marked genomic heterogeneity. Beyond structural rearrangements, a relevant role in its biology is represented by allelic imbalances leading to significant variations in ploidy status. To elucidate better the genomic complexity of MM, we analyzed a panel of 45 patients using combined FISH and microarray approaches. We firstly generated genome-wide profiles of 41 MMs and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 19396863
DOI: 10.1002/gcc.20668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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