Article
Integration of global SNP-based mapping and expression arrays reveals key regions, mechanisms, and genes important in the pathogenesis of multiple myeloma.
Blood - 1 Sept 2006
Walker Brian A, Leone Paola E, Jenner Matthew W, Li Cheng, Gonzalez David, Johnson David C, Ross Fiona M, Davies Faith E, Morgan Gareth J
Abstract excerpt
Multiple myeloma is characterized by genomic alterations frequently involving gains and losses of chromosomes. Single nucleotide polymorphism (SNP)-based mapping arrays allow the identification of copy number changes at the sub-megabase level and the identification of loss of heterozygosity (LOH) due to monosomy and uniparental disomy (UPD). We have found that SNP-based mapping array data and fluorescence in situ...
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