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Article

SirT1 is required in the male germ cell for differentiation and fecundity in mice

21 Aug 2014

Abstract excerpt

Sirtuins are NAD(+)-dependent deacylases that regulate numerous biological processes in response to the environment. SirT1 is the mammalian ortholog of yeast Sir2, and is involved in many metabolic pathways in somatic tissues. Whole body deletion of SirT1 alters reproductive function in oocytes and the testes, in part caused by defects in central neuro-endocrine control. To study the function of SirT1...

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Identifiers

PMID: 25142464
DOI: 10.1242/dev.110627

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