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Article

Male SIRT1 insufficiency leads to sperm with decreased ability to hyperactivate and fertilize

7 Jun 2022

Abstract excerpt

Abstract Deficient sperm motility is a frequent cause of the age‐related male sub‐/infertility. Since the protein sirtuin 1 (SIRT1) develops anti‐aging action and participates in sperm motility and ATP synthesis in mitochondria, we investigated its role in the acquisition of hyperactivated motility during capacitation. For this, the dynamics of sperm subpopulations were studied, using males of Sirt1+/−...

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PMID: 35668641
DOI: 10.1111/rda.14172

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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