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Dynamics and necessity of SIRT1 for maternal–zygotic transition

16 Sept 2024

Abstract excerpt

Dynamic changes in maternal‒zygotic transition (MZT) require complex regulation of zygote formation, maternal transcript decay, embryonic genome activation (EGA), and cell cycle progression. Although these changes are well described, some key regulatory factors are still elusive. Sirtuin-1 (SIRT1), an NAD + -dependent histone deacetylase, is a versatile driver of MZT via its epigenetic and nonepigenetic...

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PMID: 39285243
DOI: 10.1038/s41598-024-72595-6

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