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Article

SIRT6 in mouse spermatogenesis is modulated by diet-induced obesity

19 Aug 2011

Abstract excerpt

Male obesity is associated with reduced sperm function and increased incidence of sperm DNA damage; however, the underlying molecular mechanisms have not yet been identified. Mammalian SIRT6 protein is involved in caloric-dependant DNA damage repair in other tissue types, yet a possible role for SIRT6 in male obesity and subfertility has not been investigated previously. To assess SIRT6 levels and activity in the...

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PMID: 21871212
DOI: 10.1071/rd10326

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