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Article

Divergent roles of sirtuin 1 in human granulosa-lutein cells: similarities to human chorionic gonadotropin

6 Mar 2023

Abstract excerpt

Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates nonhistone substrates, e.g., tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ. Consequently, it regulates a wide range of physiological functions including cell cycle control, energy expenditure, oxidative stress response, apoptosis, and...

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PMID: 36881661
DOI: 10.1093/biolre/ioad026

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