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Article

Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice.

Development (Cambridge, England) - 1 Feb 2017

Liu Chao, Song Zhenhua, Wang Lina, Yu Haiyan, Liu Weixiao, Shang Yongliang, Xu Zhiliang, Zhao Haichao, Gao Fengyi, Wen Jiamin, Zhao Linan, Gui Yaoting, Jiao Jianwei, Gao Fei, Li Wei

Abstract excerpt

Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous biological processes. Sirt1-/- mice display an increased frequency of abnormal spermatozoa, but the mechanism of Sirt1 in spermiogenesis remains largely unknown. Here, we report that Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knockout mice were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28003215
DOI: 10.1242/dev.147074

Genes

GOPC
PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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