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Article

Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility

19 Jan 2018

Abstract excerpt

BACKGROUND: Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases that catalyze post-translational modifications of proteins. Together, they respond to metabolic challenges, inflammatory signals or hypoxic/oxidative stress, and are associated with aging and longevity. The role of Sirtuins in the regulation of fertility emerged in 2003 when a defective reproductive phenotype was observed in SIRT1-null...

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Ovarian function and disorders
Reproductive Biology and Fertility
Sirtuins and Resveratrol in Medicine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29447380
DOI: 10.1093/humupd/dmy003

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