Article
Sirtuins in female meiosis and in reproductive longevity
13 Nov 2020
Abstract excerpt
Abstract Transmission of genetic material through high‐quality gametes to progeny requires accurate homologous chromosome recombination and segregation during meiosis. A failure to accomplish these processes can have major consequences in reproductive health, including infertility, and development disorders in offspring. Sirtuins, a family of NAD+‐dependent protein deacetylases and ADP‐ribosyltransferases, play...
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