Article
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome.
Blood - 23 Oct 2014
Kulasekararaj Austin G, Jiang Jie, Smith Alexander E, Mohamedali Azim M, Mian Syed, Gandhi Shreyans, Gaken Joop, Czepulkowski Barbara, Marsh Judith C W, Mufti Ghulam J
Abstract excerpt
The distinction between acquired aplastic anemia (AA) and hypocellular myelodysplastic syndrome (hMDS) is often difficult, especially nonsevere AA. We postulated that somatic mutations are present in a subset of AA, and predict malignant transformation. From our database, we identified 150 AA patients with no morphological evidence of MDS, who had stored bone marrow (BM) and constitutional DNA. We excluded...
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