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Article

Subtype and Regional-Specific Neuroinflammation in Sporadic Creutzfeldt–Jakob Disease

4 Aug 2014

Abstract excerpt

The present study identifies deregulated cytokines and mediators of the immune response in the frontal cortex and cerebellum of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 and VV2 subtypes compared to age-matched controls. Deregulated genes include pro- and anti-inflammatory cytokines, toll-like receptors, colony stimulating factors, cathepsins, members of the complement system, and members of the integrin and...

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PMID: 25136317
DOI: 10.3389/fnagi.2014.00198

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