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Article

Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease

1 Jun 1999

Abstract excerpt

Progressive changes in host mRNA expression can illuminate crucial pathogenetic pathways in infectious disease. We examined general and specific approaches to mRNA expression in three rodent models of Creutzfeldt-Jakob disease (CJD). Each of these models displays distinctive neuropathology. Although mRNAs for the chemokine receptor CCR5, the lysosomal protease cathepsin S, and the pleiotropic cytokine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10233972
DOI: 10.1128/jvi.73.6.5089-5097.1999

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